Can't think of many that haven't left me in floods.
It's an age thing.
Toy Story 3 was the most emotionally draining film I have seen for years. Try watching that when your own children were the same age as the boy in the first film and you bought them Woody and Buzz dolls. And then watching no. 3 when they are all off to Uni.
Grave of the Fireflies
Will never watch it as I value my peace of mind too much and having been told the story, I know I wouldn't be able to cope.