The genre is irrelevant - no matter how insistent the producers are that "this is the end", it means nothing.
Police Academy weren't horrors.
I'm talking about recently though, and also the genre is relevent because comedy films do generally tend to spawn less sequels, in the past ten years i can't think of any examples of a comedy series that lasted longer than 3 movies (American Pie being the exception). Even the Saw films have ended for the time being. The last one of those films was in 2010 and there's no sign of them restarting that any time soon (i heard talk of a reboot, but it was just a rumour and nothing has come of it).