Kat Moon: a wonderful character in her initial 2000-05 stint; then returned in 2010 as a dreadful loudmouth bitch who went around slapping or sleeping with anything that had a pulse. The Shaggerman story is one of the worst EastEnders has ever done.
Sam Mitchell: really came into her own when Kim Medcalf was casted in the role. Sam was actually one of my favourite characters in 2004/05. Then they producers took the bizarre decision to re-recast Sam back to Daniella Westbrook, and the character returned as a blinged-up, orange-faced chav. Years of character development thrown out the window. Dreadful.
Ronnie Mitchell: Started off as an intriguing character who obviously had a dark past. Then the writers decided Ronnie should be defined purely by the endless tragedies that befall her, so she now just goes around stealing babies and murdering people. A total mess of a character.
Bianca Butcher: Actually a rather mature and sympathetic character by the time Patsy Palmer left in the late 90s. Then Bianca returned in 2008 and she had regressed by about 20 years. In fact, Bianca actually got stupider every year.
Sharon Watts The writers performed a hatchet-job on Sharon's character when she returned in 2012. It was like none of them had done any research, and clearly the writers that Kirkwood brought over from Hollyoaks had never actually watched EastEnders before 2006. Sharon went from a strong, confident, successful businesswoman, to a jealous, snobby, man-dependent mess overnight. They tried to turn her into Tanya. Thankfully a lot of this has been undone since DTC took the reins.