Has there been many?

Tony and Dom in Hollyoaks were two brothers played by two brothers

Sophie and Mel Burton, twins in Hollyoaks were played by real life twins Connie and Cassie Powney

The Alessi twins in neighbours: Gayle and Gillian (with a hard G) Blakeney

Neighbours has a real life mother and son - the actress who plays Steph and the guy who plays Josh. Their characters are not connected at all however.

I think Sophie and Faye from Corrie are cousins

Steven and Peter Beale in EastEnders were played by brothers Stuart and Alex Stevens for about a year in the 90s.

Lacey Turners sister played the legendary Shenice. Jac Jossas cousin Megan played Courtney Mitchell.

In Hollyoaks, Texas's mother was played by the actress's own mother

William Roaches sons played his son and grandson too didn't they? And I think Anne Haddys husband turned up in Neighbours at some point.

I think Cain and Rhona (ED) are married in real life.

Isn't Ellen Thomas who plays Claudette in EastEnders Ann Mitchell's mother in real life?

Lindsey Coulson is Patsy Palmer's sister-in-law, as she is married to Patsy's brother. They are mother and daughter in EE.

Chris Chittell (Eric Pollard) and Lesley Dunlop (Brenda Walker) are partners.

The actors who play Debbie and David in ED are a couple.

Lots of Coronation Street marriages ...

Pat Phoenix (Elsie Tanner) was married to Alan Browning who played her screen husband Alan Howard.

Sue Nicholls (Audrey) is married to Mark Eden (Alan Bradley).

Anne Kirkbride met her husband David Beckett when he was cast as Deirdre's boyfriend, Dave Barton.

Jane Danson's husband Robert Beck appeared briefly as Jimmy Dockerson a number of years ago.

Also, Ellie Leach (Faye Windass) is Brooke Vincent's cousin.

I'm sure there are more.

Rebekah and Sebastian Elmaloglou were both in Home and Away. I think they're cousins in real life.

There's plenty of Neighbours connections

Olympia Valance (Paige Smith) is Holly valance's (Flick Scully) half-sister

Stephanie McIntosh (Sky Mangel) is Jason Donavan's (Scott Robinson) half sister and his dad Terence Donavan played Doug Willis

Nell Feeney (Janelle Timmins) was married to Shane Connor (Joe Scully)

Siblings David Tom and Heather Tom were both on the Young and the Restless and strangely after they both left their characters Billy and Victoria were paired together so I guess neither of them can return, they also played siblings on One Life to Live.

On Days of Our Lives Deidre Hall's twin sister (whose name I forget) also played Marlena's twin in the 80's then later returned in the '00s as a Marlena look a like.

Back in the 90s Emmerdale Rachel Hughes and her brother (think he was called Mark) were played by real life brother and sister.

The actors who played Kim and Chris Tate (step mother and son) were married in real life.

Joe and Shana Swash played Mickey and Demi Miller in EastEnders.

William Roache's sons have appeared in Corrie alongside him. Linus played Peter Barlow from 1973 to 1975 and later Ken's long lost son Lawrence Cunningham in 2010. Roache's other son James played his grandson by the same name in 2010 and 2011.

His second wife Sara played a Judge at Tracy's trial in 2007.

Holly Valance and Olympia Valance are sisters (Neighbours)

Terence and Jason Donovan are father and son (Neighbours)

Might have already been mentioned, but Megan Jossa (Courtney Mitchell), and Jac Jossa (My future wife, all round sex-goddess MyLauren) are cousins.