Hi there,
Here's what I've done with all my hamsters:
Line the bottom of the cage with thick newspaper. Don't use sawdust etc. because that can cause skin and eye problems. Provide a mix of bedding material - a mix of shredded newspaper, toilet paper, bits of wool, fabric, commercial stuff, etc.. and she'll make a nice nest for herself.
Wherever she normally pees, you can put her toilet. I use a coffee jar with a flat side.. You need to put something she has already peed on in there so she'll smell it and go there to pee. Each day, remove the jar, rinse it out and replace it. The smell will linger.. If you're not going to empty the jar every day, line it with something absorbent.
Every week, remove 1/4 or 1/3 of her bedding and supply new stuff, so her bedding is gradually being refreshed. At the same time, take a peek at her food stores and take away any fresh food, as it will turn everything mouldy. If you let the hamster organise her environment, she'll keep it very clean and orderly. Don't disturb the cage more than that otherwise she'll get confused and pee all over the place. It's really stressful for hamsters to have their cages completely turned out, and it's unnecessary. If you find that she's storing her droppings in a pile somewhere, you could remove those when you do her cage. If you organise the cage like that your work will be minimal.
Even with an interesting environment, hamsters need a lot of stimulation, so keep adding new things for her to explore and enjoy.. Cardboard egg boxes with holes in them, extra ladders, sprigs of lavender and other scented harmless plants, etc.. Also, give her some nice fresh food each day - a variety of wee pieces of greens, celery, red pepper - just a variety of little pieces so she'll eat them all and not store them.. You can also hang up millet seed sprays and other bird treats so she'll have to climb up to get them.
If you live alone, you can hand-tame your hamster, hamster-proof the home and let your hamster out to run around for an hour or two every night. (They're nocturnal so they sleep until late in the evening). (You have to put all electrical flexes out of their reach, as they might chew them, and seal every tiny crack in skirting boards, under doors, etc. Hamsters can almost flatten themselves and get through spaces of less than 1cm.) Supervise them carefully when you first let them out, so you can pinpoint potential hazards. Leave the cage on the floor so she'll be able to climb back in when she feels like it. I've done this with all my hamsters. Over time, once I knew the hamsters were safe, I'd keep the cage on the bedroom floor, and open it when I went to bed.. I'd go to sleep with the hamster running around the room, then when I awoke, the hamster would be tucked back up in its bed, and I'd close the cage. One time I awoke with the hamster running up my leg under the duvet during the night.. hehehe.
If the cage is managed the way I described above, with a happy hamster keeping the house in order, they're happy to go back into their cage and won't try to make a nest anywhere else. If they don't go back into the cage themselves, then close the cage door so they cannot go in and out to help themselves to food, then when they're hungry put some nice smelling cheese and peanuts into the cage and they'll soon hop back in and you can shut the cage door.
You always take a slight risk in letting your little pet run loose, but if you are careful they have a far happier life and I think that the risk's worth taking. Same as when you let your cat run loose outside or let the dog off the lead.