It's no lie that this was the most successful panel ever. This panel was well loved and popular. For some reason these 4 just worked together.

What is it these 4 have that the other panels have never been able to match up too?

Even when it was Simon, Louis, Cheryl, and someone = it still wasnt the same

Thats my favourite panel ever on the show but i don't think it was just down to them, the talent was good/great for each of the 3 seasons, the show itself was more believable and Simon and Cheryl both seemed (to me) to be in much happier spirits.

Cheryl's my favourite judge ever on the show and while i still like her her last 2 seasons just weren't the same.

I think it was just everything about the show at the time that bounced off each other. We just hold the panel in particular high regard because it's the most obvious.