The key political issue won't be brexit. It will be the NHS. May will try and say the efficency measures are locally decided by experts, but the reality will create a high stink in all constituencies. Looking at my local proposals, they involve concentrating from 2 to one main hospital, 60 minute ambulance runs to the remaining full scale hospital, and fewer beds. Locally, the 3000 beds currently available, are due to fall to 2800, but, by 2021, a rising population, and an aging one, will increase demand to 3600. The plan is to cut that to 2600. Elective operations will fall by 17% and inpatient stays will be limited to 10 days. This simply won't work, and will produce demonstrations all over the place. May is going to have to find a lot of money to avoid losing votes.
The Lords will be the biggest problem for brexit
internationally ,Trump is worryingly likely to prove a dangerous halfwit, early on.
Russia will prove difficult , and continue to support states Trump has a problem with.
Iran has an election and won't take kindly to changes to the nuclear agreement. Nor will Europe, China or Russia. Israel won't tolerate Iran building Iranian bases in Syria, or Lebanon, so there's a problem ready to explode there too.
China isn't going to respond well to Trump, attacking its economic policy , or interfering more in its security zone.
And in the background, N Korea is getting nearer and nearer to having a working ICBM, with a nuclear warhead, that can hit the US - while taking it out, will cause a war, that will make Iraq look like a tea party.
ISIS will lose nearly all its territory by 2018. But the war in Syria will go on.