Just like
Tinalou, I'm really hoping the two departing cast member's aren't George and Ronnie!
I really dont think Amanda and Jimmi are the two departing cast members because they've only recently arrived, and dont forget, Jimmi was brought in because Ben left to go travelling, so a new male doctor was needed. Then again, the way things are going at the moment with the two of them, anything could happen.
I personally think one of the departing cast member is Faith. I dont know, her character has been really dull for months, and all she seems to be doing to sticking her nose into other people's business, especially regarding finding Greg a bloke - she's obsessed!

The writers have made no attempt with the character of late, and that's why I'm thinking that she MAY be the one cast member that'll be departing. I really cant think of another cast member, but I wouldn't be surprised if, sadly, it was Greg as he's not had a lot of storylines these past few months, well, except for the Mantis storyline.
On one hand, it would make sense if a couple was to go, either Amanda and Jimmi or George and Ronnie, because the way out would be easy as they are both married. But, on the other hand, two unconnected characters COULD be departing and go either together, or a few weeks after one another, therefore not leaving a huge gap. I think we have a way to go with the Amanda and Jimmy situation, and with George due to give birth in a few weeks, and Ronnie being a proper cast member within the last few months, as opposed to guest starring, they seem pretty settled for the time being!