I would love to see all the housemates be strangers, after last season they really need to rest the "housemate relationship" twists.
Second, I would like to see more viewer involvement, out of all 9 seasons of BB USA the ninth edition was the least interactive out of all. Normally the American public gets to give the housemates of their choice special treats like a phone call from home, special dinner with another housemate of their choice, a luxury not in the house, etc.
Despite the fact the American public can't vote out housemates (except in BB1/BB8) the "America's Choice" still stirs up the house. Like in BB6 USA the "Friendship" alliance thought America liked them but voted Janelle (a member of the other alliance) a phone call from home the "friendship" cried and April even had the nerve to say the producer's rigged the vote and America was a piece of sh**. BB10 needs more viewer input, simple.
Third a twist that would shock the house would be (I think) if America could vote in the eviction process again. Like something similar to BB8 USA where the viewing public controlled one housemates vote. In BB10 USA the producer's could give America one eviction vote a week and let America chose who they want out while the rest of the house votes like normal.